Some leakage or discharge after using a vaginal suppository is normal and expected. As the suppository dissolves inside the vagina, the ingredients can become more liquid and may naturally work their way back out. The amount of discharge can vary from person to person and may also depend on when and how the suppository is used.

For this reason, we recommend inserting the suppository at bedtime, when you can remain lying down afterward. You may also want to wear a pantyliner or pad to protect your underwear and pajamas, particularly when you are first using the treatment.

Experiencing more leakage does not necessarily mean that you used the suppository incorrectly or that the treatment did not work. Some of the medication and its base will be absorbed, while the remaining material may be released as discharge.

If you experience discharge that is unusual for you, has a strong or unpleasant odor, or is accompanied by significant irritation, itching, pain, or other concerning symptoms, contact your healthcare provider for guidance.

Compounding medicine is the process of creating customized medications or therapeutic formulations prepared by a licensed compounding pharmacy under the direction of a healthcare provider. Unlike mass-produced medications, compounded therapies can be tailored to meet a patient’s specific needs, including the type of ingredient used, strength, route of delivery, or formulation base.

In vaginal care, compounding may be used when standard commercial products do not fully address a patient’s symptoms, sensitivities, or tissue needs. This can be especially important for cancer survivors and menopausal patients experiencing vaginal dryness, irritation, tissue fragility, or discomfort.

Compounded vaginal therapies may allow healthcare providers to:

• Customize localized treatment approaches
• Select nonhormonal or tissue-supportive ingredients
• Choose a formulation base designed for sensitive tissue
• Adjust delivery methods for comfort and tolerability
• Support long-term maintenance care under clinical supervision

Because vaginal health can be influenced by tissue condition, hormone changes, and the vaginal microbiome, some clinicians use compounded therapies as part of a broader, personalized care plan focused on comfort, tolerability, and symptom support.

Yes, our products are thoughtfully formulated and designed to address specific vaginal health needs at different stages of life. Whether you're managing menopausal dryness, vulvar conditions, post-cancer symptoms, or other common vaginal concerns, we offer a range of products.

BiomeNourish® is our proprietary vaginal and vulvar base designed to support vaginal health. Formulated using our Bio-Match® technology, it’s designed to align with the natural vaginal environment—supporting tissue comfort, promoting microbiome stability, and improving the tolerability of prescription treatments.

Unlike many conventional compounding bases that may include ingredients which can compromise vaginal microbiome health, BiomeNourish® is intentionally formulated to support both tissue and microbiome balance.

BiomeNourish® is available in both cream and suppository forms, allowing care teams to choose the format best suited to your symptoms and treatment plan.

For more details on how BiomeNourish® works and what makes it different, visit our BiomeNourish® formulation page.